The international break is over and Matchweek 4 of the Premier League arrives with one of the biggest fixtures the calendar can offer a Manchester derby at Old Trafford. Below is our full round of predictions, key stats, and betting angles for every game across the weekend, from Bournemouth vs Brentford on Saturday to the derby finale on Sunday.
Saturday 12 September
Aston Villa vs Nottingham Forest
Villa have started the season needing a spark going forward, while Forest have looked organised but toothless away from the City Ground. Expect Villa to edge a cagey encounter in front of their home crowd. Prediction: Aston Villa to win, Under 2.5 goals
Bournemouth vs Brentford
Both sides like to press high and create chances through transition, which should make for an open, end-to-end match. Bournemouth’s home form has been solid, but Brentford travel well and rarely go missing at set pieces. Prediction: Both Teams to Score – Yes, narrow scoreline
Chelsea vs Hull City
On paper this is the most one-sided fixture of the round. Chelsea’s squad depth and home advantage should be enough to see off a Hull side adjusting to Premier League pace. Prediction: Chelsea to win, Over 2.5 goals
Crystal Palace vs Ipswich Town
Palace have been difficult to break down at Selhurst Park, and Ipswich’s away form remains a work in progress. A low-scoring home win looks the shrewd play here. Prediction: Crystal Palace to win
Liverpool vs Fulham
Liverpool’s attacking trio have looked sharp in the opening weeks, and Fulham have historically struggled at Anfield. Expect the champions to control possession and convert their chances. Prediction: Liverpool to win, Over 2.5 goals
Tottenham vs Everton
Spurs have shown flashes of quality but also defensive lapses this season. Everton have been resilient under their current setup and could frustrate Tottenham for large spells. Prediction: Draw or narrow Tottenham win
Sunderland vs Arsenal
Arsenal go into this as strong favourites against a newly promoted Sunderland side still finding their feet at this level. Expect the visitors’ superior quality to tell in the second half. Prediction: Arsenal to win
Sunday 13 September
Coventry City vs Brighton
A tricky one to call with limited recent data between these sides at this level. Brighton’s possession-based approach should give them the edge, but Coventry’s home crowd will make it uncomfortable. Prediction: Brighton to win, Under 2.5 goals
Manchester United vs Manchester City – Match of the Weekend
The derby always throws up drama regardless of league position, and this year is no different with both sides looking to build momentum. City’s control of midfield tempo has been a hallmark of recent meetings, but United have shown more fight at Old Trafford this season than in previous years. Expect a tight, high-intensity contest that could be settled by a moment of individual quality rather than a tactical mismatch. Prediction: Manchester City to win narrowly, Both Teams to Score – Yes
🏆 Kalaso VIP Tip of the Weekend
Our highest-confidence pick for Matchweek 4 combines Liverpool’s home scoring form with Arsenal’s away quality: Liverpool to win & Over 2.5 goals, combined with Arsenal to win at Sunderland.
How We Arrive at Our Predictions
As always, our picks are built on:
- Head-to-head history between the sides
- Current goal difference and attacking output
- Defensive solidity and clean sheet records
- Home and away form splits
- Shots on target and expected goals trends
- Team news, injuries, and rotation risk
Remember to always gamble responsibly and treat predictions as informed guidance rather than guarantees.
Odds and lineups can shift closer to kick-off — check our Predictions page on match day for any late updates.